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Jordan, Craig

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Dr. Jordan completed his bachelor’s degree at the University of California, Berkeley, followed by doctoral studies at Princeton University with a focus on the molecular biology of hematopoietic stem cells. He then went on to perform post-doctoral studies at the Whitehead Institute. He next spent several years working in the biotechnology industry before rejoining the academic ranks in 1997 at the University of Kentucky as an Assistant Professor of medicine. In 2003 he moved to the University of Rochester, where he became the Director of Translational Research for Hematologic Malignancies at the James P. Wilmot Cancer Center. In 2013 he was recruited to his present position, Chief of the Hematology Division at the University of Colorado Denver Medical Center.

One or more keywords matched the following items that are connected to Jordan, Craig

Item Type	Name
Academic Article	Primitive hemopoietic stem cells: direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations.
Academic Article	High-resolution cell cycle analysis of defined phenotypic subsets within primitive human hematopoietic cell populations.
Academic Article	Relative to adult marrow, fetal liver repopulates nearly five times more effectively long-term than short-term.
Academic Article	Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors.
Academic Article	Recent progress in identifying genes regulating hematopoietic stem cell function and fate.
Academic Article	The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells.
Academic Article	Transduction of primitive human hematopoietic cells with recombinant adenovirus vectors.
Academic Article	A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations.
Academic Article	The return of clonal marking sheds new light on human hematopoietic stem cells.
Academic Article	The use of adenoviral vectors for genetic manipulation and analysis of primitive hematopoietic cells.
Academic Article	Adenovirus vectors for gene transduction into mobilized blood CD34+ cells.
Academic Article	Considerations for targeting malignant stem cells in leukemia.
Academic Article	Cancer stem cell biology: from leukemia to solid tumors.
Academic Article	Differential outcomes of human cytomegalovirus infection in primitive hematopoietic cell subpopulations.
Academic Article	Clonal and systemic analysis of long-term hematopoiesis in the mouse.
Academic Article	Feverfew: weeding out the root of leukaemia.
Academic Article	The potential of targeting malignant stem cells as a treatment for leukemia.
Academic Article	Parathyroid hormone stimulates expression of the Notch ligand Jagged1 in osteoblastic cells.
Academic Article	Searching for leukemia stem cells--not yet the end of the road?
Academic Article	The leukemic stem cell.
Academic Article	Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8).
Academic Article	Preferential loss of mismatch repair function in refractory and relapsed acute myeloid leukemia: potential contribution to AML progression.
Academic Article	Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data.
Academic Article	The biologic properties of leukemias arising from BCR/ABL-mediated transformation vary as a function of developmental origin and activity of the p19ARF gene.
Academic Article	Cancer stem cells: controversial or just misunderstood?
Academic Article	The increasing complexity of the cancer stem cell paradigm.
Academic Article	Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1).
Academic Article	Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials.
Academic Article	Modulation of cell surface protein free thiols: a potential novel mechanism of action of the sesquiterpene lactone parthenolide.
Academic Article	NCI first International Workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the committee on the biological considerations of hematological relapse following allogeneic stem cell transplantation unrelated to graft-versus-tumor effects: state of the science.
Academic Article	Regulation of myeloid leukaemia by the cell-fate determinant Musashi.
Academic Article	A novel in vitro assay of tumor-initiating cells in xenograft prostate tumors.
Academic Article	Leukemia stem cells and microenvironment: biology and therapeutic targeting.
Academic Article	Melampomagnolide B: a new antileukemic sesquiterpene.
Academic Article	Isolation and characterization of primitive hematopoietic cells based on their position in the cell cycle.
Academic Article	Expression of tumor-suppressor genes interferon regulatory factor 1 and death-associated protein kinase in primitive acute myelogenous leukemia cells.
Academic Article	Proteasome inhibition in myelodysplastic syndromes and acute myelogenous leukemia cell lines.
Academic Article	Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia.
Academic Article	Noncanonical NF-?B signaling regulates hematopoietic stem cell self-renewal and microenvironment interactions.
Academic Article	A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit.
Academic Article	Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells.
Academic Article	Long-term repopulating abilities of enriched fetal liver stem cells measured by competitive repopulation.
Academic Article	Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis.
Academic Article	Cellular and molecular characterization of the role of the flk-2/flt-3 receptor tyrosine kinase in hematopoietic stem cells.
Academic Article	The hematopoietic stem cell in myelodysplasia.
Academic Article	The level of mRNA encoding the amphotropic retrovirus receptor in mouse and human hematopoietic stem cells is low and correlates with the efficiency of retrovirus transduction.
Academic Article	Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.
Academic Article	Cellular and developmental properties of fetal hematopoietic stem cells.
Academic Article	Transduction efficiency of cell lines and hematopoietic stem cells correlates with retrovirus receptor mRNA levels.
Academic Article	Targeting the most critical cells: approaching leukemia therapy as a problem in stem cell biology.
Academic Article	Efficient and durable gene marking of hematopoietic progenitor cells in nonhuman primates after nonablative conditioning.
Academic Article	Genetic manipulation of primitive leukemic and normal hematopoietic cells using a novel method of adenovirus-mediated gene transfer.
Academic Article	Mechanisms controlling pathogenesis and survival of leukemic stem cells.
Academic Article	The molecular basis of leukemia.
Academic Article	The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells.
Academic Article	An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells.
Academic Article	The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target.
Academic Article	Cancer stem cells.
Academic Article	Can we finally target the leukemic stem cells?
Academic Article	The novel nuclear factor-kappaB inhibitor LC-1 is equipotent in poor prognostic subsets of chronic lymphocytic leukemia and shows strong synergy with fludarabine.
Academic Article	Lessons learned from the study of JunB: new insights for normal and leukemia stem cell biology.
Academic Article	Monoclonal antibodies against IREM-1: potential for targeted therapy of AML.
Academic Article	Leukemia stem cells in a genetically defined murine model of blast-crisis CML.
Academic Article	Protein kinase C-associated kinase is required for NF-kappaB signaling and survival in diffuse large B-cell lymphoma cells.
Academic Article	Targeting myeloid leukemia stem cells.
Academic Article	High-risk acute lymphoblastic leukemia cells with bcr-abl and INK4A/ARF mutations retain susceptibility to alloreactive T cells.
Academic Article	In vivo prostaglandin E2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells.
Academic Article	The NF (Nuclear factor)-?B inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells.
Academic Article	Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways.
Academic Article	Leukemia stem cells in 2010: current understanding and future directions.
Academic Article	Discovery of 1,2,4-thiadiazolidine-3,5-dione analogs that exhibit unusual and selective rapid cell death kinetics against acute myelogenous leukemia cells in culture.
Academic Article	Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104.
Academic Article	Leukemia stemness signatures step toward the clinic.
Academic Article	How close are we to targeting the leukemia stem cell?
Academic Article	BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells.
Concept	Precursor Cell Lymphoblastic Leukemia-Lymphoma
Concept	Hematopoietic Stem Cells
Concept	Cell Death
Concept	Active Transport, Cell Nucleus
Concept	Lymphoma, Large B-Cell, Diffuse
Concept	Neoplasms, Plasma Cell
Concept	Cell Lineage
Concept	Neoplastic Stem Cells
Concept	Hematopoietic Stem Cell Transplantation
Concept	HeLa Cells
Concept	Cell Nucleus
Concept	Cell Division
Concept	Cell Survival
Concept	Receptors, Cell Surface
Concept	Cell Adhesion
Concept	Cell Cycle
Concept	Cell Membrane
Concept	Cell Culture Techniques
Concept	Stem Cell Factor
Concept	Clone Cells
Concept	Myeloid Progenitor Cells
Concept	K562 Cells
Concept	B-Cell Activating Factor
Concept	Cell Transformation, Neoplastic
Concept	Dendritic Cells
Concept	Cell-Derived Microparticles
Concept	Granulocyte Precursor Cells
Concept	Neoplastic Cells, Circulating
Concept	Cell Size
Concept	Stem Cell Transplantation
Concept	Stromal Cells
Concept	Cell Line
Concept	3T3 Cells
Concept	Tumor Stem Cell Assay
Concept	Tumor Cells, Cultured
Concept	Hematopoietic Stem Cell Mobilization
Concept	Cell Differentiation
Concept	Lymphoid Progenitor Cells
Concept	Cell Line, Transformed
Concept	Bone Marrow Cells
Concept	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Concept	Leukemia, Lymphocytic, Chronic, B-Cell
Concept	Myeloid Cells
Concept	Killer Cells, Natural
Concept	Cell Line, Tumor
Concept	Antibody-Dependent Cell Cytotoxicity
Concept	Cells, Cultured
Concept	Stem Cells
Concept	Cell Hypoxia
Concept	Cell Separation
Concept	Cell Proliferation
Concept	Cell Count
Academic Article	In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling.
Academic Article	Novel mTOR inhibitory activity of ciclopirox enhances parthenolide antileukemia activity.
Academic Article	Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells.
Academic Article	Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity.
Academic Article	Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C-H functionalization.
Academic Article	Metabolic effects of acute thiamine depletion are reversed by rapamycin in breast and leukemia cells.
Academic Article	Aldehyde dehydrogenases in acute myeloid leukemia.
Academic Article	The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation.
Academic Article	Selenium suppresses leukemia through the action of endogenous eicosanoids.
Academic Article	Selective activity of the histone deacetylase inhibitor AR-42 against leukemia stem cells: a novel potential strategy in acute myelogenous leukemia.
Academic Article	Protein kinase C-associated kinase regulates NF-?B activation through inducing IKK activation.
Academic Article	Targeting acute myeloid leukemia stem cells: a review and principles for the development of clinical trials.
Academic Article	Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity.
Academic Article	Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations.
Academic Article	Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia.
Academic Article	Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics.
Academic Article	Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline.
Academic Article	Dimers of Melampomagnolide B Exhibit Potent Anticancer Activity against Hematological and Solid Tumor Cells.
Academic Article	Clonality of neutrophilia associated with plasma cell neoplasms: report of a SETBP1 mutation and analysis of a single institution series.
Academic Article	Acute myeloid leukaemia.
Academic Article	Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche.
Academic Article	Chemoenzymatic synthesis and antileukemic activity of novel C9- and C14-functionalized parthenolide analogs.
Academic Article	Evolution of acute myelogenous leukemia stem cell properties after treatment and progression.
Academic Article	Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells.
Academic Article	ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.
Academic Article	Rational design of a parthenolide-based drug regimen that selectively eradicates acute myelogenous leukemia stem cells.
Academic Article	Identification of a melampomagnolide B analog as a potential lead molecule for treatment of acute myelogenous leukemia.
Academic Article	Therapeutic targeting of acute myeloid leukemia stem cells.
Academic Article	Design, synthesis and evaluation of anti-CD123 antibody drug conjugates.
Academic Article	Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1.
Grant	Cellular and Molecular Studies of Leukemic Stem Cellss
Grant	Oncogene Cooperativity in Leukemia Stem Cells
Grant	Amnis ImageStream Flow Cytometer
Grant	Selective in vivo Ablation of Leukemia Stem Cells
Grant	Characterization and targeting of leukemia stem cell metabolism
Academic Article	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
Academic Article	Succinamide derivatives of melampomagnolide B and their anti-cancer activities.
Academic Article	A Small-Molecule Inhibitor of WEE1, AZD1775, Synergizes with Olaparib by Impairing Homologous Recombination and Enhancing DNA Damage and Apoptosis in Acute Leukemia.
Grant	Microenvironment-induced metabolic plasticity in leukemia stem cells
Academic Article	Micelle Delivery of Parthenolide to Acute Myeloid Leukemia Cells.
Academic Article	AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells.
Academic Article	MMB triazole analogs are potent NF-?B inhibitors and anti-cancer agents against both hematological and solid tumor cells.
Academic Article	Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes.
Academic Article	Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells.
Academic Article	MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity.
Academic Article	Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia.
Academic Article	Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.
Academic Article	Why are hypomethylating agents or low-dose cytarabine and venetoclax so effective?
Academic Article	Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.
Academic Article	Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling.
Concept	Cell Self Renewal
Concept	Cell- and Tissue-Based Therapy
Concept	Programmed Cell Death 1 Receptor
Concept	MCF-7 Cells
Concept	HEK293 Cells
Concept	Primary Cell Culture
Concept	RAW 264.7 Cells
Concept	Pre-B-Cell Leukemia Transcription Factor 1
Academic Article	Targeting Glutamine Metabolism and Redox State for Leukemia Therapy.
Academic Article	The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells.
Academic Article	Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II.
Academic Article	CD123 CAR T cells for the treatment of myelodysplastic syndrome.
Grant	Therapeutic Targeting of MDS Stem Cells
Academic Article	Can we selectively target AML stem cells?
Grant	Metabolic mechanisms of venetoclax resistance in acute myeloid leukemia stem cells
Academic Article	Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors.
Academic Article	Delivery of a model lipophilic membrane cargo to bone marrow via cell-derived microparticles.
Academic Article	Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells.
Academic Article	The Hepatic Microenvironment Uniquely Protects Leukemia Cells through Induction of Growth and Survival Pathways Mediated by LIPG.
Grant	Therapeutic Targeting of Human AML Stem Cells
Academic Article	MDS-associated SF3B1 mutations enhance proinflammatory gene expression in patient blast cells.
Academic Article	Exploiting Protein Translation Dependence in Multiple Myeloma with Omacetaxine-Based Therapy.
Academic Article	Enriching for human acute myeloid leukemia stem cells using reactive oxygen species-based cell sorting.
Academic Article	Targeting Energy Metabolism in Cancer Stem Cells: Progress and Challenges in Leukemia and Solid Tumors.
Academic Article	PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress.
Academic Article	Fatty acid metabolism underlies venetoclax resistance in acute myeloid leukemia stem cells.
Academic Article	Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization.
Academic Article	Antitumor properties of novel sesquiterpene lactone analogs as NF?B inhibitors that bind to the IKK? ubiquitin-like domain (ULD).
Academic Article	The STAT3-MYC axis promotes survival of leukemia stem cells by regulating SLC1A5 and oxidative phosphorylation.
Academic Article	Integrative analysis of drug response and clinical outcome in acute myeloid leukemia.
Academic Article	Outcomes Are Similar After Allogeneic Hematopoietic Stem Cell Transplant for Newly Diagnosed Acute Myeloid Leukemia Patients who Received Venetoclax?+?Azacitidine Versus Intensive Chemotherapy.
Academic Article	Therapeutic resistance in acute myeloid leukemia cells is mediated by a novel ATM/mTOR pathway regulating oxidative phosphorylation.
Academic Article	HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia.
Academic Article	Therapy-Resistant Acute Myeloid Leukemia Stem Cells Are Resensitized to Venetoclax + Azacitidine by Targeting Fatty Acid Desaturases 1 and 2.
Academic Article	A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy.
Academic Article	Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium.
Academic Article	Parthenolide As a Therapeutic for Disseminated Canine Neoplasms.

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